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Food coloring Regulation

Food colorings are tested for safety by various bodies around the world and sometimes different bodies have different views on food color safety. In the United States, FD&C (generally indicates that the FDA has approved the colorant for use in foods, drugs and cosmetics) numbers are given to approved synthetic food dyes that do not exist in nature, while in the European Union, E numbers are used for all additives, both synthetic and natural, that are approved in food applications.
Most other countries have their own regulations and list of food colors which can be used in various applications, including maximum daily intake limits.
Natural colors are not required to be tested by a number of regulatory bodies throughout the world, including the United States FDA. The FDA lists "color additives exempt from certification" for food in subpart A of the Code of Federal Regulations - Title 21 Part 73. However, this list contains substances which may have synthetic origins.